Prevalence of Delayed Neuropathy and Intermediate Syndrome in Acute Organophosphorus Poisoning: A Cross-sectional Toxicological/Clinical Study

Background: Organophosphates are among the most common causes of poisoning worldwide—responsible for 3 million and 200000 deaths every year. Nearly 15% people who poisoned die. This cross-sectional toxicological/clinical study aimed to investigate prevalence influential factors in incidence delayed peripheral neuropathy intermediate syndrome acute with organophosphorus toxins. The was conducted Loghman Hakim Hospital, Tehran City, Iran, from 2017 2020. Methods: data were obtained patients’ records during follow-up. Data included demographic information (age, sex, etc.), vital signs, muscarinic, nicotinic, neurological symptoms at admission, atropine therapy status, pralidoxime intake status. Post-discharge complications obtained, Electromyography (EMG) Nerve Conduction Velocity (NCV) results recorded evaluated hospitalization Statistical analysis performed using SPSS software, version 22. Results: Of 63 studied patients, 61.9% female. Mean±SD age patients 31.90±13.128 years. Male significantly (P<0.010) older than female ones. muscarinic nausea vomiting (73.2%), diarrhea (34.92%), abdominal pain (33.33%). Regarding nicotinic symptoms, sweating (30.16%) fasciculation (19.05%) commonest. Neurological less common; seizures observed cases (4.76%) coma 2 (3.17%). Most (79.4%) received atropine. days treatment 5.51±3.52 4.06±4.62 days, respectively. Only one death recorded. initial EMG-NCV test on second day showed abnormalities 4 (6.3%), indicating presence syndrome. Conclusion: tests our follow-up (30 days) no abnormalities. Hence seen. During hospitalization, patient had flaccid paralysis significant impairment (P<0.01).